- Original Article
- The large-conductance calcium-activated potassium channel holds the key to the conundrum of familial hypokalemic periodic paralysis
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June-Bum Kim, Sung-Jo Kim, Sun-Yang Kang, Jin Woong Yi, Seung-Min Kim
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Clin Exp Pediatr. 2014;57(10):445-450. Published online October 31, 2014
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Purpose Familial hypokalemic periodic paralysis (HOKPP) is an autosomal dominant channelopathy characterized by episodic attacks of muscle weakness and hypokalemia. Mutations in the calcium channel gene, CACNA1S, or the sodium channel gene, SCN4A, have been found to be responsible for HOKPP; however, the mechanism that causes hypokalemia remains to be determined. The aim of this study was to improve the understanding... |
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